Research Education

Welcome to the Omni-Biotic® Research and Education resource center. Here you will find a variety of reviews, meta analyses, and clinical studies. Where a specific probiotic formulation is studied, it is most often referred to with the European brand name, but the formulations we offer in the United States are identical to the original.

Omni-Biotic AB 10

CLINICAL STUDY #1

Probiotic Therapy of Gastrointestinal Symptoms During COVID-19

Published: 2024

Authors: Horvath et al
Study Type: Randomized Controlled Trial (RCT)
Related Omni-Biotic Formulation: AB 10

  • Omni-Biotic AB 10 significantly modulated gut microbiome composition and diversity in COVID-19 patients
  • Results demonstrated E. faecium colonization
Read full study

CLINICAL STUDY #2

Probiotic OMNi-BiOTiC® 10 AAD Reduces Cyclophosphamide-Induced Inflammation and Adipose Tissue Wasting in Mice

Published: 2023

Authors: Obermüller et al
Study Type: Preclinical
Related Omni-Biotic Formulation: AB 10

  • Omni-Biotic AB 10 ameliorated body weight loss and preserved adipose tissue
  • Intervention reduced intestinal permeability
  • Intervention reduced colonic inflammation and goblet cell loss
Read full study

CLINICAL STUDY #3

"Insights into the Composition of a Co-Culture of 10 Probiotic Strains (OMNi BiOTiC® AAD10) and Effects of Its Postbiotic Culture Supernatant"

Published: 2020

Study Type: Preclinical
Related Omni-Biotic Formulation: AB 10

  • Antifungal Activity
  • Antibacterial Activity
  • Gut Microbiome Supportive
Read full study

CLINICAL STUDY #4

"Effect of a Multispecies Probiotic on Intestinal and Skin Colonization by Multidrug Resistant Gram Negative Bacteria in Patients in a Long Term Care Facility"

Published: 2020

Study Type: pilot study
Related Omni-Biotic Formulation: AB 10

  • <58% reduction in multidrug resistant gram negative infection (stool)
  • <72% reduction in multidrug resistant gram negative infection (skin)
  • Demonstrated safety and efficacy in long term care facilities
Read full study

CLINICAL STUDY #5

"Probiotics Use for Antibiotic Associated Diarrhea: A Pragmatic Participatory Evalution in Nursing Homes"

Published: 2020

Study Type: participatory evaluation
Related Omni-Biotic Formulation: AB 10

  • 16% reduction in antibiotic associated diarrhea
  • Demonstrated safety and efficacy in nursing homes
Read full study

CLINICAL STUDY #6

"Probiotics in Clostridium difficile infection: reviewing the need for a multistrain probiotic"

Published: 2013

Study Type: pilot study
Related Omni-Biotic Formulation: AB 10

  • Complete resolution of Clostridium difficile infection
Read full study

CLINICAL STUDY #7

"Use of a multi-species probiotic for the prevention of antibiotic associated diarrhea"

Published: 2010

Study Type: observational study
Related Omni-Biotic Formulation: AB 10

This observational study demonstrated the successful use of Omni-Biotic AB 10 (AAD) for primary prevention of antibiotic associated diarrhea in post surgical patients.

Read full study

CLINICAL STUDY #8

"Probiotics for the prevention of antibiotic-associated diarrhea and Clostridium difficile infection among hospitalized patients: systematic review and meta-analysis"

Published: 2013

Study Type: review article
Related Omni-Biotic Formulation: AB 10

This systematic review and meta-analysis evaluated the efficacy of co-administration of probiotics with antibiotics. Findings demonstrated that probiotics used concurrently with antibiotics reduce the risk of antibiotic associated diarrhea and C. difficile infection.

Read full study

CLINICAL STUDY #1

Probiotic Therapy of Gastrointestinal Symptoms During COVID-19

Published: 2024

Authors: Horvath et al
Study Type: Randomized Controlled Trial (RCT)
Related Omni-Biotic Formulation: AB 10

  • Omni-Biotic AB 10 significantly modulated gut microbiome composition and diversity in COVID-19 patients
  • Results demonstrated E. faecium colonization
Read full study

CLINICAL STUDY #2

Probiotic OMNi-BiOTiC® 10 AAD Reduces Cyclophosphamide-Induced Inflammation and Adipose Tissue Wasting in Mice

Published: 2023

Authors: Obermüller et al
Study Type: Preclinical
Related Omni-Biotic Formulation: AB 10

  • Omni-Biotic AB 10 ameliorated body weight loss and preserved adipose tissue
  • Intervention reduced intestinal permeability
  • Intervention reduced colonic inflammation and goblet cell loss
Read full study

CLINICAL STUDY #3

"Insights into the Composition of a Co-Culture of 10 Probiotic Strains (OMNi BiOTiC® AAD10) and Effects of Its Postbiotic Culture Supernatant"

Published: 2020

Study Type: Preclinical
Related Omni-Biotic Formulation: AB 10

  • Antifungal Activity
  • Antibacterial Activity
  • Gut Microbiome Supportive
Read full study

CLINICAL STUDY #4

"Effect of a Multispecies Probiotic on Intestinal and Skin Colonization by Multidrug Resistant Gram Negative Bacteria in Patients in a Long Term Care Facility"

Published: 2020

Study Type: pilot study
Related Omni-Biotic Formulation: AB 10

  • <58% reduction in multidrug resistant gram negative infection (stool)
  • <72% reduction in multidrug resistant gram negative infection (skin)
  • Demonstrated safety and efficacy in long term care facilities
Read full study

CLINICAL STUDY #5

"Probiotics Use for Antibiotic Associated Diarrhea: A Pragmatic Participatory Evalution in Nursing Homes"

Published: 2020

Study Type: participatory evaluation
Related Omni-Biotic Formulation: AB 10

  • 16% reduction in antibiotic associated diarrhea
  • Demonstrated safety and efficacy in nursing homes
Read full study

CLINICAL STUDY #6

"Probiotics in Clostridium difficile infection: reviewing the need for a multistrain probiotic"

Published: 2013

Study Type: pilot study
Related Omni-Biotic Formulation: AB 10

  • Complete resolution of Clostridium difficile infection
Read full study

CLINICAL STUDY #7

"Use of a multi-species probiotic for the prevention of antibiotic associated diarrhea"

Published: 2010

Study Type: observational study
Related Omni-Biotic Formulation: AB 10

This observational study demonstrated the successful use of Omni-Biotic AB 10 (AAD) for primary prevention of antibiotic associated diarrhea in post surgical patients.

Read full study

CLINICAL STUDY #8

"Probiotics for the prevention of antibiotic-associated diarrhea and Clostridium difficile infection among hospitalized patients: systematic review and meta-analysis"

Published: 2013

Study Type: review article
Related Omni-Biotic Formulation: AB 10

This systematic review and meta-analysis evaluated the efficacy of co-administration of probiotics with antibiotics. Findings demonstrated that probiotics used concurrently with antibiotics reduce the risk of antibiotic associated diarrhea and C. difficile infection.

Read full study

Omni-Biotic Stress Release

CLINICAL STUDY #1

The beneficial effect of a multispecies probiotic intervention on quality of sleep - a randomized, double-blinded, placebo-controlled study

Published: 2026

Authors: Horvath et al.
Study Type: Randomized Controlled Trial (RCT)
Related Omni-Biotic Formulation: Stress Release

  • Stress Release significantly improved overall sleep quality vs. placebo after 4 weeks of use
  • Faster sleep onset (reduced sleep latency) and improved sleep efficiency, key drivers of better sleep
  • Probiotic strains were recovered in the gut microbiome, confirming survival and measurable microbiome modulation
Read full study

CLINICAL STUDY #2

Multi-species probiotic supplement enhances vagal nerve function – results of a randomized controlled trial in patients with depression and healthy controls

Published: 2025

Authors: Mörkl et al.
Study Type: Randomized Controlled Trial (RCT)
Related Omni-Biotic Formulation: Stress Release

  • Omni-Biotic Stress Release supplementation led to significant improvements in vagal nerve function (via HRV) in patients with major depression
  • The intervention was associated with favorable microbiome shifts, including increased Akkermansia muciniphila
  • Participants showed improvements in sleep parameters (e.g., reduced sleep latency)
Read full study

CLINICAL STUDY #3

Clinical Treatment of Functional Pain Syndromes along the Microbiome–Gut–Brain Axis: Combined Approach with Neuromodulation–Neurofeedback and Multispecies Probiotic

Published: 2024

Authors: Castelletti et al.
Study Type: Interventional Study
Related Omni-Biotic Formulation: Stress Release

  • Omni-Biotic Stress Release in combination with neurofeedback and psychological support led to substantial improvement in pain relief (from 36.6% to 87.3%)
  • The intervention resulted in significant reduction in stress biomarkers (cortisol) and anxiety
  • The intervention improved brain regulation (increased alpha–theta activity)
Read full study

CLINICAL STUDY #4

Positive Effects of Probiotic Therapy in Patients with Post-Infectious Fatigue

Published: 2023

Authors: Obermoser et al.
Study Type: Randomized Controlled Trial (RCT)
Related Omni-Biotic Formulation: Stress Release

  • Omni-Biotic Stress Release supplementation resulted in greater reductions in fatigue severity over 6 months
  • Omni-Biotic Stress Release supplementation resulted in greater reductions in symptoms over 6 months
  • The intervention led to significant improvements in quality of life scores
Read full study

CLINICAL STUDY #5

A Probiotic to Improve Sleep Quality during COVID-19 Pandemic: A Questionnaire Study

Published: 2023

Authors: Horvath et al.
Study Type: Observational Study
Related Omni-Biotic Formulation: Stress Release

  • Omni-Biotic Stress Release (~2 week duration) led to marked improvements in sleep quality, mental health, and vitality
  • Omni-Biotic Stress Release led to marked improvements in mental health and vitality
  • The intervention resulted in improved stress resilience and overall quality of life
Read full study

CLINICAL STUDY #6

Interleukin-6 Gene Expression Changes after a 4-Week Intake of a Multispecies Probiotic in Major Depressive Disorder—Preliminary Results of the PROVIT Study

Published: 2020

Authors: Reiter et al.
Study Type: Randomized Controlled Trial (RCT)
Related Omni-Biotic Formulation: Stress Release

  • Omni-Biotic Stress Release use resulted in inflammatory gene expression modulation, particularly IL-6 (systemic inflammation)
  • Results highlight the link between microbiome modulation and immune pathways in depression
  • Findings indicate Omni-Biotic Stress Release may serve as a well-tolerated adjunctive approach in major depressive disorder
Read full study

CLINICAL STUDY #7

Probiotic Treatment in Individuals with Euthymic Bipolar Disorder: A Pilot-Study on Clinical Changes and Compliance

Published: 2020

Authors: Reininghaus et al.
Study Type: Pilot Study
Related Omni-Biotic Formulation: Stress Release

  • High adherence and tolerability: 81.5% completed all 3 visits, and 85% of planned probiotic doses were taken.
  • GI quality-of-life improvements: approximately one-third reported reduced flatulence and easier, more frequent bowel movements during treatment.
  • Psychological benefit signals: cognitive reactivity to sad mood decreased, and manic symptom scores were significantly reduced
Read full study

CLINICAL STUDY #8

"Effects of Probiotic Strains on Disease Activity and Enteric Permeability in Psoriatic Arthritis–A Pilot Open-Label Study"

Published: 2020

Study Type: pilot clinical
Related Omni-Biotic Formulation: Stress Release

  • Reduction in psoriatic arthritis disease activity
  • Reduced in fecal zonulin (marker of intestinal permeability)
  • Reduced fecal calprotectin (marker of intestinal inflammation)
Read full study

CLINICAL STUDY #9

"Influence of 4-week multi-strain probiotic administration on resting state functional connectivity in healthy volunteers"

Published: 2019

Study Type: double blind, randomized controlled trial
Related Omni-Biotic Formulation: Stress Release

  • Decreased functional connectivity in default mode, middle and superior frontal gyrus networks
  • Increased functional connectivity in salience network (cingulate gyrus and precuneus cortex)
  • Brain activity shift indicative of less connectivity associated with ruminative thought and more connectivity associated with executive function
Read full study

CLINICAL STUDY #10

"Probiotics drive gut microbiome triggering emotional brain signatures"

Published: 2018

Study Type: double blind, randomized controlled trial
Related Omni-Biotic Formulation: Stress Release

  • Improved positive affect and cognitive reactivity
  • Improved memory performance
  • Improved gut microbiome diversity
Read full study

CLINICAL STUDY #11

"Effects of an oral synbiotic on the gastrointestinal immune system and microbiota in patients with diarrhea-predominant irritable bowel syndrome"

Published: 2019

Study Type: observational trial
Related Omni-Biotic Formulation: Stress Release

  • Increased gut microbiome diversity and short chain fatty acid production
  • Reduced inflammatory CD4+ T cells and fecal zonulin levels
  • Decreased IBS disease severity
Read full study

CLINICAL STUDY #12

"The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems"

Published: 2015

Study Type: review article
Related Omni-Biotic Formulation: Stress Release

This review summarizes the available evidence describing the bi-directional gut-brain relationship including neural, endocrine, immune, and humoral pathways. It also explores relevant pathophysiological mechanisms.

Read full study

CLINICAL STUDY #13

"Stress and the Microbiota–Gut–Brain Axis in Visceral Pain: Relevance to Irritable Bowel Syndrome"

Published: 2015

Study Type: review article
Related Omni-Biotic Formulation: Stress Release

This review highlights the evidence supporting the connection between stress and the gut microbiota, with specific focus on the mechanisms by which the microbiota impacts stress response, behavior, and visceral pain.

Read full study

CLINICAL STUDY #1

The beneficial effect of a multispecies probiotic intervention on quality of sleep - a randomized, double-blinded, placebo-controlled study

Published: 2026

Authors: Horvath et al.
Study Type: Randomized Controlled Trial (RCT)
Related Omni-Biotic Formulation: Stress Release

  • Stress Release significantly improved overall sleep quality vs. placebo after 4 weeks of use
  • Faster sleep onset (reduced sleep latency) and improved sleep efficiency, key drivers of better sleep
  • Probiotic strains were recovered in the gut microbiome, confirming survival and measurable microbiome modulation
Read full study

CLINICAL STUDY #2

Multi-species probiotic supplement enhances vagal nerve function – results of a randomized controlled trial in patients with depression and healthy controls

Published: 2025

Authors: Mörkl et al.
Study Type: Randomized Controlled Trial (RCT)
Related Omni-Biotic Formulation: Stress Release

  • Omni-Biotic Stress Release supplementation led to significant improvements in vagal nerve function (via HRV) in patients with major depression
  • The intervention was associated with favorable microbiome shifts, including increased Akkermansia muciniphila
  • Participants showed improvements in sleep parameters (e.g., reduced sleep latency)
Read full study

CLINICAL STUDY #3

Clinical Treatment of Functional Pain Syndromes along the Microbiome–Gut–Brain Axis: Combined Approach with Neuromodulation–Neurofeedback and Multispecies Probiotic

Published: 2024

Authors: Castelletti et al.
Study Type: Interventional Study
Related Omni-Biotic Formulation: Stress Release

  • Omni-Biotic Stress Release in combination with neurofeedback and psychological support led to substantial improvement in pain relief (from 36.6% to 87.3%)
  • The intervention resulted in significant reduction in stress biomarkers (cortisol) and anxiety
  • The intervention improved brain regulation (increased alpha–theta activity)
Read full study

CLINICAL STUDY #4

Positive Effects of Probiotic Therapy in Patients with Post-Infectious Fatigue

Published: 2023

Authors: Obermoser et al.
Study Type: Randomized Controlled Trial (RCT)
Related Omni-Biotic Formulation: Stress Release

  • Omni-Biotic Stress Release supplementation resulted in greater reductions in fatigue severity over 6 months
  • Omni-Biotic Stress Release supplementation resulted in greater reductions in symptoms over 6 months
  • The intervention led to significant improvements in quality of life scores
Read full study

CLINICAL STUDY #5

A Probiotic to Improve Sleep Quality during COVID-19 Pandemic: A Questionnaire Study

Published: 2023

Authors: Horvath et al.
Study Type: Observational Study
Related Omni-Biotic Formulation: Stress Release

  • Omni-Biotic Stress Release (~2 week duration) led to marked improvements in sleep quality, mental health, and vitality
  • Omni-Biotic Stress Release led to marked improvements in mental health and vitality
  • The intervention resulted in improved stress resilience and overall quality of life
Read full study

CLINICAL STUDY #6

Interleukin-6 Gene Expression Changes after a 4-Week Intake of a Multispecies Probiotic in Major Depressive Disorder—Preliminary Results of the PROVIT Study

Published: 2020

Authors: Reiter et al.
Study Type: Randomized Controlled Trial (RCT)
Related Omni-Biotic Formulation: Stress Release

  • Omni-Biotic Stress Release use resulted in inflammatory gene expression modulation, particularly IL-6 (systemic inflammation)
  • Results highlight the link between microbiome modulation and immune pathways in depression
  • Findings indicate Omni-Biotic Stress Release may serve as a well-tolerated adjunctive approach in major depressive disorder
Read full study

CLINICAL STUDY #7

Probiotic Treatment in Individuals with Euthymic Bipolar Disorder: A Pilot-Study on Clinical Changes and Compliance

Published: 2020

Authors: Reininghaus et al.
Study Type: Pilot Study
Related Omni-Biotic Formulation: Stress Release

  • High adherence and tolerability: 81.5% completed all 3 visits, and 85% of planned probiotic doses were taken.
  • GI quality-of-life improvements: approximately one-third reported reduced flatulence and easier, more frequent bowel movements during treatment.
  • Psychological benefit signals: cognitive reactivity to sad mood decreased, and manic symptom scores were significantly reduced
Read full study

CLINICAL STUDY #8

"Effects of Probiotic Strains on Disease Activity and Enteric Permeability in Psoriatic Arthritis–A Pilot Open-Label Study"

Published: 2020

Study Type: pilot clinical
Related Omni-Biotic Formulation: Stress Release

  • Reduction in psoriatic arthritis disease activity
  • Reduced in fecal zonulin (marker of intestinal permeability)
  • Reduced fecal calprotectin (marker of intestinal inflammation)
Read full study

CLINICAL STUDY #9

"Influence of 4-week multi-strain probiotic administration on resting state functional connectivity in healthy volunteers"

Published: 2019

Study Type: double blind, randomized controlled trial
Related Omni-Biotic Formulation: Stress Release

  • Decreased functional connectivity in default mode, middle and superior frontal gyrus networks
  • Increased functional connectivity in salience network (cingulate gyrus and precuneus cortex)
  • Brain activity shift indicative of less connectivity associated with ruminative thought and more connectivity associated with executive function
Read full study

CLINICAL STUDY #10

"Probiotics drive gut microbiome triggering emotional brain signatures"

Published: 2018

Study Type: double blind, randomized controlled trial
Related Omni-Biotic Formulation: Stress Release

  • Improved positive affect and cognitive reactivity
  • Improved memory performance
  • Improved gut microbiome diversity
Read full study

CLINICAL STUDY #11

"Effects of an oral synbiotic on the gastrointestinal immune system and microbiota in patients with diarrhea-predominant irritable bowel syndrome"

Published: 2019

Study Type: observational trial
Related Omni-Biotic Formulation: Stress Release

  • Increased gut microbiome diversity and short chain fatty acid production
  • Reduced inflammatory CD4+ T cells and fecal zonulin levels
  • Decreased IBS disease severity
Read full study

CLINICAL STUDY #12

"The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems"

Published: 2015

Study Type: review article
Related Omni-Biotic Formulation: Stress Release

This review summarizes the available evidence describing the bi-directional gut-brain relationship including neural, endocrine, immune, and humoral pathways. It also explores relevant pathophysiological mechanisms.

Read full study

CLINICAL STUDY #13

"Stress and the Microbiota–Gut–Brain Axis in Visceral Pain: Relevance to Irritable Bowel Syndrome"

Published: 2015

Study Type: review article
Related Omni-Biotic Formulation: Stress Release

This review highlights the evidence supporting the connection between stress and the gut microbiota, with specific focus on the mechanisms by which the microbiota impacts stress response, behavior, and visceral pain.

Read full study

Omni-Biotic Balance

CLINICAL STUDY #1

An Indication-Specific Multi-Species Probiotic Reduces Skin Problems and Significantly Reduces Allergy Symptoms and Susceptibility to Infections

Published: 2025

Authors: Kolleritsch & Auinger
Study Type: Observational study, 1,400 participants
Related Omni-Biotic Formulation: Balance

  • 83% improvement in skin complaints after 8 weeks
  • 81% improvement in symptoms of atopic dermatitis
  • 84% improvement in Urticaria symptoms
  • 87% reduction in allergy complaints such as runny nose and itchy eyes
  • 87% reduction in GI complaints
Read full study

CLINICAL STUDY #2

Identification of Strong Interleukin-10 Inducing Lactic Acid Bacteria Which Downregulate T Helper Type 2 Cytokines

Published: 2005

Authors: Niers et al
Study Type: Preclinical
Related Omni-Biotic Formulation: PandA; Balance

This study identified the ability of Omni-Biotic PandA to modulate the production of inflammation influencing cytokines and divert the immune system in a regulatory or tolerant mode.

  • Omni-Biotic Balance probiotic strains strongly induced IL-10 production (immune tolerance)
  • Omni-Biotic Balance strains downregulate Th2 cytokines e.g., IL-4, IL-5, IL-13 (allergic response)
  • Omni-Biotic Balance strains shift immune balance toward regulatory/Treg responses
Read full study

CLINICAL STUDY #3

"Homeostatic Immunity and the Microbiota"

Published: 2017

Study Type: review article
Related Omni-Biotic Formulation: Balance

This review explores the roles the microbiome plays in the development and function of the immune system.

Read full study

CLINICAL STUDY #4

"Role of the Microbiota in Immunity and Inflammation"

Published: 2014

Study Type: review article
Related Omni-Biotic Formulation: Balance

This review discusses the relationship between the gut microbiome and immunity highlighting the influence of modern diet, pharmaceuticals and hygiene on rising rates of inflammatory and autoimmune disorders.

Read full study

CLINICAL STUDY #1

An Indication-Specific Multi-Species Probiotic Reduces Skin Problems and Significantly Reduces Allergy Symptoms and Susceptibility to Infections

Published: 2025

Authors: Kolleritsch & Auinger
Study Type: Observational study, 1,400 participants
Related Omni-Biotic Formulation: Balance

  • 83% improvement in skin complaints after 8 weeks
  • 81% improvement in symptoms of atopic dermatitis
  • 84% improvement in Urticaria symptoms
  • 87% reduction in allergy complaints such as runny nose and itchy eyes
  • 87% reduction in GI complaints
Read full study

CLINICAL STUDY #2

Identification of Strong Interleukin-10 Inducing Lactic Acid Bacteria Which Downregulate T Helper Type 2 Cytokines

Published: 2005

Authors: Niers et al
Study Type: Preclinical
Related Omni-Biotic Formulation: PandA; Balance

This study identified the ability of Omni-Biotic PandA to modulate the production of inflammation influencing cytokines and divert the immune system in a regulatory or tolerant mode.

  • Omni-Biotic Balance probiotic strains strongly induced IL-10 production (immune tolerance)
  • Omni-Biotic Balance strains downregulate Th2 cytokines e.g., IL-4, IL-5, IL-13 (allergic response)
  • Omni-Biotic Balance strains shift immune balance toward regulatory/Treg responses
Read full study

CLINICAL STUDY #3

"Homeostatic Immunity and the Microbiota"

Published: 2017

Study Type: review article
Related Omni-Biotic Formulation: Balance

This review explores the roles the microbiome plays in the development and function of the immune system.

Read full study

CLINICAL STUDY #4

"Role of the Microbiota in Immunity and Inflammation"

Published: 2014

Study Type: review article
Related Omni-Biotic Formulation: Balance

This review discusses the relationship between the gut microbiome and immunity highlighting the influence of modern diet, pharmaceuticals and hygiene on rising rates of inflammatory and autoimmune disorders.

Read full study

Omni-Biotic Hetox

CLINICAL STUDY #1

Naturopathic Management to Taper Off Glucagon-Like Peptide-1 Receptor Agonist Therapy in Type 2 Diabetes

Published: 2025

Authors: Linder, L
Study Type: Case Study
Related Omni-Biotic Formulation: Hetox

Omni-Biotic Hetox (as a component of a comprehensive naturopathic medicine regimen) supported GLP-1 improvements over an 8-week period post prescription discontinuation:

  • Weight loss maintenance
  • Improved glycemic control
  • Improved lipid profile
  • Improved micronutrient levels
Read full study

CLINICAL STUDY #2

Probiotics in Incretin-Based Therapy for Patient Living with Obesity: A Synergistic Approach

Published: 2024

Authors: Mattioli et al.
Study Type: Observational Study
Related Omni-Biotic Formulation: Hetox

  • The combination of Omni-Biotic Hetox and low-dose liraglutide produced metabolic outcomes comparable to higher-dose GLP-1 therapy alone
  • Lower dose GLP-1 therapy resulted in significant reduction in adverse effects (e.g., GI symptoms) with improved tolerability and adherence
  • Omni-Biotic Hetox provides a synergistic effect on metabolic regulation allowing for effective obesity management at lower drug doses
Read full study

CLINICAL STUDY #3

Effect of Oral Multispecies Probiotic on Wound Healing, Periodontitis and Quality of Life in Patients with Diabetes

Published: 2024

Authors: Stuermer et al.
Study Type: Pilot Study
Related Omni-Biotic Formulation: Hetox

  • ~38% of patients achieved complete wound healing with the Omni-Biotic Hetox intervention
  • Additional patients showed >50% wound size reduction
  • Omni-Biotic Hetox resulted in reduced pathogenic wound bacteria, inflammation, and pain
Read full study

CLINICAL STUDY #4

Diesel Exhaust Particle Inhalation in Conjunction with High-Fat Diet Consumption Alters the Expression of Pulmonary SARS-CoV-2 Infection Pathways, Which Is Mitigated by Probiotic Treatment in C57BL/6 Male Mice

Published: 2024

Authors: Nguyen-Alley et al.
Study Type: Preclinical Study
Related Omni-Biotic Formulation: Hetox

  • Combined exposure to diesel exhaust particles + high-fat diet increased expression of SARS-CoV-2 entry-related proteins
  • Environmental pollutant exposure and diet created a pro-inflammatory, high-risk pulmonary environment linked to respiratory disease vulnerability
  • Omni-Biotic Hetox mitigated molecular changes, reduced expression of infection-related pathways and provided a protective, anti-inflammatory effect.
Read full study

CLINICAL STUDY #5

Changes in the Intestinal Microbiome during a Multispecies Probiotic Intervention in Compensated Cirrhosis

Published: 2020

Authors: Horvath et al.
Study Type: Randomized Controlled Trial (RCT)
Related Omni-Biotic Formulation: Hetox

  • Omni-Biotic Hetox supplementation enriched the gut microbiome with beneficial taxa, including increases in Faecalibacterium prausnitzii
  • The intervention resulted in reduced fecal zonulin, indicating improved intestinal barrier integrity (reduced permeability)
  • Omni-Biotic Hetox-induced microbiome changes were associated with immune modulation (increased neopterin), suggestive of systemic immunologic effects
Read full study

CLINICAL STUDY #6

Migraine Prophylaxis with a Probiotic: Results of an Uncontrolled Observational Study with 1,020 Patients

Published: 2018

Authors: Straube et al.
Study Type: Observational Study
Related Omni-Biotic Formulation: Hetox

  • Omni-Biotic Hetox use was associated with reduced frequency of migraine episodes
  • The intervention reduced the intensity of migraine-associated symptoms
  • Proposed mechanism includes reduced gut permeability and systemic inflammation, linking gut health to migraine pathophysiology
Read full study

CLINICAL STUDY #7

"Randomised clinical trial: the effects of a multispecies probiotic vs. placebo on innate immune function, bacterial translocation and gut permeability in patients with cirrhosis"

Published: 2016

Study Type: double blind, randomized controlled trial
Related Omni-Biotic Formulation: Hetox

  • Increased neutrophil resting burst and neopterin levels 
  • Improvement in liver function
  • Demonstrated safety and efficacy in stable liver cirrhosis
Read full study

CLINICAL STUDY #8

"Effects of a multi-strain probiotic supplement for 12 weeks in circulating endotoxin levels and cardiometabolic profiles of medication naïve T2DM patients: a randomized clinical trial"

Published: 2017

Study Type: double blind, randomized controlled trial
Related Omni-Biotic Formulation: Hetox

  • Reduced abdominal adiposity (hip:waist ratio)
  • Improved HOMA-IR
  • Demonstrated safety and efficacy in medication naive T2DM
Read full study

CLINICAL STUDY #9

"Effects of a 6-month multi-strain probiotics supplementation in endotoxemic, inflammatory and cardiometabolic status of T2DM patients: A randomized, double-blind, placebo-controlled trial"

Published: 2018

Study Type: double blind, randomized controlled trial
Related Omni-Biotic Formulation: Hetox

  • Reduced circulating endotoxin levels (70%)
  • Reduced metabolic markers: glucose (38%), insulin (38%), HOMA-IR (64%), triglycerides (48%), total cholesterol (19%), total/HDL-cholesterol ratio (19%)
  • Reduced inflammatory markers: TNF-α (67%), IL-6 (77%), CRP (53%), resistin (53%)
Read full study

CLINICAL STUDY #10

"The gut-liver axis and the intersection with the microbiome"

Published: 2018

Study Type: review article
Related Omni-Biotic Formulation: Hetox

This review discusses gut-liver communications in various forms of liver disease and the potential to use the microbiome to determine the stage of liver disease as well as predicting the effects of dietary and pharmaceutical interventions.

Read full study

CLINICAL STUDY #1

Naturopathic Management to Taper Off Glucagon-Like Peptide-1 Receptor Agonist Therapy in Type 2 Diabetes

Published: 2025

Authors: Linder, L
Study Type: Case Study
Related Omni-Biotic Formulation: Hetox

Omni-Biotic Hetox (as a component of a comprehensive naturopathic medicine regimen) supported GLP-1 improvements over an 8-week period post prescription discontinuation:

  • Weight loss maintenance
  • Improved glycemic control
  • Improved lipid profile
  • Improved micronutrient levels
Read full study

CLINICAL STUDY #2

Probiotics in Incretin-Based Therapy for Patient Living with Obesity: A Synergistic Approach

Published: 2024

Authors: Mattioli et al.
Study Type: Observational Study
Related Omni-Biotic Formulation: Hetox

  • The combination of Omni-Biotic Hetox and low-dose liraglutide produced metabolic outcomes comparable to higher-dose GLP-1 therapy alone
  • Lower dose GLP-1 therapy resulted in significant reduction in adverse effects (e.g., GI symptoms) with improved tolerability and adherence
  • Omni-Biotic Hetox provides a synergistic effect on metabolic regulation allowing for effective obesity management at lower drug doses
Read full study

CLINICAL STUDY #3

Effect of Oral Multispecies Probiotic on Wound Healing, Periodontitis and Quality of Life in Patients with Diabetes

Published: 2024

Authors: Stuermer et al.
Study Type: Pilot Study
Related Omni-Biotic Formulation: Hetox

  • ~38% of patients achieved complete wound healing with the Omni-Biotic Hetox intervention
  • Additional patients showed >50% wound size reduction
  • Omni-Biotic Hetox resulted in reduced pathogenic wound bacteria, inflammation, and pain
Read full study

CLINICAL STUDY #4

Diesel Exhaust Particle Inhalation in Conjunction with High-Fat Diet Consumption Alters the Expression of Pulmonary SARS-CoV-2 Infection Pathways, Which Is Mitigated by Probiotic Treatment in C57BL/6 Male Mice

Published: 2024

Authors: Nguyen-Alley et al.
Study Type: Preclinical Study
Related Omni-Biotic Formulation: Hetox

  • Combined exposure to diesel exhaust particles + high-fat diet increased expression of SARS-CoV-2 entry-related proteins
  • Environmental pollutant exposure and diet created a pro-inflammatory, high-risk pulmonary environment linked to respiratory disease vulnerability
  • Omni-Biotic Hetox mitigated molecular changes, reduced expression of infection-related pathways and provided a protective, anti-inflammatory effect.
Read full study

CLINICAL STUDY #5

Changes in the Intestinal Microbiome during a Multispecies Probiotic Intervention in Compensated Cirrhosis

Published: 2020

Authors: Horvath et al.
Study Type: Randomized Controlled Trial (RCT)
Related Omni-Biotic Formulation: Hetox

  • Omni-Biotic Hetox supplementation enriched the gut microbiome with beneficial taxa, including increases in Faecalibacterium prausnitzii
  • The intervention resulted in reduced fecal zonulin, indicating improved intestinal barrier integrity (reduced permeability)
  • Omni-Biotic Hetox-induced microbiome changes were associated with immune modulation (increased neopterin), suggestive of systemic immunologic effects
Read full study

CLINICAL STUDY #6

Migraine Prophylaxis with a Probiotic: Results of an Uncontrolled Observational Study with 1,020 Patients

Published: 2018

Authors: Straube et al.
Study Type: Observational Study
Related Omni-Biotic Formulation: Hetox

  • Omni-Biotic Hetox use was associated with reduced frequency of migraine episodes
  • The intervention reduced the intensity of migraine-associated symptoms
  • Proposed mechanism includes reduced gut permeability and systemic inflammation, linking gut health to migraine pathophysiology
Read full study

CLINICAL STUDY #7

"Randomised clinical trial: the effects of a multispecies probiotic vs. placebo on innate immune function, bacterial translocation and gut permeability in patients with cirrhosis"

Published: 2016

Study Type: double blind, randomized controlled trial
Related Omni-Biotic Formulation: Hetox

  • Increased neutrophil resting burst and neopterin levels 
  • Improvement in liver function
  • Demonstrated safety and efficacy in stable liver cirrhosis
Read full study

CLINICAL STUDY #8

"Effects of a multi-strain probiotic supplement for 12 weeks in circulating endotoxin levels and cardiometabolic profiles of medication naïve T2DM patients: a randomized clinical trial"

Published: 2017

Study Type: double blind, randomized controlled trial
Related Omni-Biotic Formulation: Hetox

  • Reduced abdominal adiposity (hip:waist ratio)
  • Improved HOMA-IR
  • Demonstrated safety and efficacy in medication naive T2DM
Read full study

CLINICAL STUDY #9

"Effects of a 6-month multi-strain probiotics supplementation in endotoxemic, inflammatory and cardiometabolic status of T2DM patients: A randomized, double-blind, placebo-controlled trial"

Published: 2018

Study Type: double blind, randomized controlled trial
Related Omni-Biotic Formulation: Hetox

  • Reduced circulating endotoxin levels (70%)
  • Reduced metabolic markers: glucose (38%), insulin (38%), HOMA-IR (64%), triglycerides (48%), total cholesterol (19%), total/HDL-cholesterol ratio (19%)
  • Reduced inflammatory markers: TNF-α (67%), IL-6 (77%), CRP (53%), resistin (53%)
Read full study

CLINICAL STUDY #10

"The gut-liver axis and the intersection with the microbiome"

Published: 2018

Study Type: review article
Related Omni-Biotic Formulation: Hetox

This review discusses gut-liver communications in various forms of liver disease and the potential to use the microbiome to determine the stage of liver disease as well as predicting the effects of dietary and pharmaceutical interventions.

Read full study

Omni-Biotic Power

CLINICAL STUDY #1

Probiotic Supplements Beneficially Affect Tryptophan-Kynurenine Metabolism and Reduce the Incidence of Upper Respiratory Tract Infections in Trained Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial.

Published: 2016

Authors: Strasser, et al
Study Type: Randomized Controlled Trial (RCT)
Related Omni-Biotic Formulation: Power

  • Reduced exercise induced tryptophan degradation
  • Decreased upper respiratory tract infections
Read full study

CLINICAL STUDY #2

Probiotic Supplementation affects Markers of Intestinal Barrier, Oxidation, and Inflammation in Trained Men; a randomized, double-blinded, placebo-controlled trial.

Published: 2012

Authors: Lamprecht, et al
Study Type: Randomized Controlled Trial (RCT)
Related Omni-Biotic Formulation: Power

Significant improvements in:

  • Zonulin levels
  • Carbonyl proteins (oxidative stress marker)
  • TNF-α
Read full study

CLINICAL STUDY #1

Probiotic Supplements Beneficially Affect Tryptophan-Kynurenine Metabolism and Reduce the Incidence of Upper Respiratory Tract Infections in Trained Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial.

Published: 2016

Authors: Strasser, et al
Study Type: Randomized Controlled Trial (RCT)
Related Omni-Biotic Formulation: Power

  • Reduced exercise induced tryptophan degradation
  • Decreased upper respiratory tract infections
Read full study

CLINICAL STUDY #2

Probiotic Supplementation affects Markers of Intestinal Barrier, Oxidation, and Inflammation in Trained Men; a randomized, double-blinded, placebo-controlled trial.

Published: 2012

Authors: Lamprecht, et al
Study Type: Randomized Controlled Trial (RCT)
Related Omni-Biotic Formulation: Power

Significant improvements in:

  • Zonulin levels
  • Carbonyl proteins (oxidative stress marker)
  • TNF-α
Read full study

Omni-Biotic Panda

CLINICAL STUDY #1

"Identification of Strong Interleukin-10 Inducing Lactic Acid Bacteria which Down-Regulate T Helper Type 2 Cytokines"

Published: 2005

Study Type: preclinical analysis
Related Omni-Biotic Formulation: PandA

  • Decreased Th2 cytokine production
  • Diversion of immune system into regulatory/tolerant mode
Read full study

CLINICAL STUDY #2

"Selection of Probiotic Bacteria for Prevention of Allergic Diseases: Immunomodulation of Neonatal Dendritic Cells"

Published: 2007

Study Type: preclinical analysis
Related Omni-Biotic Formulation: PandA

  • Skewed neonatal naive T Cells toward Th1
  • Up-regulation of co-stimulatory molecules
  • No skewing toward Th2
Read full study

CLINICAL STUDY #3

"The Effects of Selected Probiotic Strains on the Development of Eczema (the PandA study)"

Published: 2009

Study Type: double blind, randomized controlled trial
Related Omni-Biotic Formulation: PandA

  • Decreased in vitro production of IL-5
  • Increased Lc. lactis colonization
  • Reduced incidence of eczema in high-risk children
Read full study

CLINICAL STUDY #4

"Probiotic Supplementation Influences Faecal Short Chain Fatty Acids in Infants at High Rick for Eczema"

Published: 2015

Study Type: double blind, randomized controlled trial: follow-on
Related Omni-Biotic Formulation: PandA

  • Increased short chain fatty acid and lactate production
  • Decreased lactose and succinate levels
  • Demonatrated safety and efficacy in children at risk to develop eczema
Read full study

CLINICAL STUDY #5

"Probiotics and Primary Prevention of Atopic Dermatitis: A Meta-Analysis of Randomized Controlled Studies"

Published: 2014

Study Type: review article
Related Omni-Biotic Formulation: PandA

This meta analysis found that probiotics have a protective role in atopic dermatitis (eczema) prevention when administered during the pre- and post-natal period.

Read full study

CLINICAL STUDY #1

"Identification of Strong Interleukin-10 Inducing Lactic Acid Bacteria which Down-Regulate T Helper Type 2 Cytokines"

Published: 2005

Study Type: preclinical analysis
Related Omni-Biotic Formulation: PandA

  • Decreased Th2 cytokine production
  • Diversion of immune system into regulatory/tolerant mode
Read full study

CLINICAL STUDY #2

"Selection of Probiotic Bacteria for Prevention of Allergic Diseases: Immunomodulation of Neonatal Dendritic Cells"

Published: 2007

Study Type: preclinical analysis
Related Omni-Biotic Formulation: PandA

  • Skewed neonatal naive T Cells toward Th1
  • Up-regulation of co-stimulatory molecules
  • No skewing toward Th2
Read full study

CLINICAL STUDY #3

"The Effects of Selected Probiotic Strains on the Development of Eczema (the PandA study)"

Published: 2009

Study Type: double blind, randomized controlled trial
Related Omni-Biotic Formulation: PandA

  • Decreased in vitro production of IL-5
  • Increased Lc. lactis colonization
  • Reduced incidence of eczema in high-risk children
Read full study

CLINICAL STUDY #4

"Probiotic Supplementation Influences Faecal Short Chain Fatty Acids in Infants at High Rick for Eczema"

Published: 2015

Study Type: double blind, randomized controlled trial: follow-on
Related Omni-Biotic Formulation: PandA

  • Increased short chain fatty acid and lactate production
  • Decreased lactose and succinate levels
  • Demonatrated safety and efficacy in children at risk to develop eczema
Read full study

CLINICAL STUDY #5

"Probiotics and Primary Prevention of Atopic Dermatitis: A Meta-Analysis of Randomized Controlled Studies"

Published: 2014

Study Type: review article
Related Omni-Biotic Formulation: PandA

This meta analysis found that probiotics have a protective role in atopic dermatitis (eczema) prevention when administered during the pre- and post-natal period.

Read full study