A complex, bidirectional communications network exists between the gut and the central nervous system which includes the brain, spinal cord, hormonal pathways and the gut associated lymphoid tissue (the gut’s immune system or GALT). Imbalances in the gut can result in toxin leakage, inflammation, and related mood and cognition symptoms including brain fog, anxiety, and stress.
Clinical studies have demonstrated the psychobiotic power of OMNi-BiOTiC® Stress Release with outcomes including improved mood, decision making, cognitive understanding, and memory.
Functional brain connectivity changes were observed in the default mode network, salience network, and middle and superior frontal gyrus network among three groups randomly assigned to receive a probiotic formulation, a placebo, or nothing at all (controls). The Omni-Biotic Stress Release probiotic group showed a significant increase in salience network activity (associated with increased attention, perception, cognition) and significant decrease in default mode network and MFGN activity (associated with reduced distraction and improved reasoning, decision-making, learning, and creativity).
This review highlights the evidence supporting the connection between stress and the gut microbiota, with specific focus on the mechanisms by which the microbiota impacts stress response, behavior, and visceral pain.